PARTNER 2

Dr. Joan Ballesteros, PhD, Chief Scientific Officer

Vivia Biotech, Parque Científico de Madrid ,PTM c/ Grisolia 2, 28760 Tres Cantos, Madrid, SPAIN

ROLE AND CONTRIBUTION

Founder and Chief Scientist of OrphaMed, will direct scientific activities within the company and the coordination with the academic teams.

SCIENTIFIC PROFILE

Chemist 1987 Univ. Barcelona (Spain), Ph.D. (1997) and Post-Doctoral studies in Biomedical Sciences Mount Sinai Hospital in New York, NYU (USA) in structure-function studies of drug activity. In 1999 started a new biotech in San Diego, automating flow cytometry techniques to develop a new multiplexing screening platform.

CAPACITY TO PROVIDE CONTRIBUTION

In 1999 he founded as Chief Scientific Officer Novasite Pharmaceuticals in San Diego, CA (USA), where he developed the core technology that forms the basis of the ExviTech platform used at OrphaMed. He left Novasite in Dec 2005 and joined OrphaMed in 2006, developing ExviTech with new IP.

TEAM MEMBERS

Joan Ballesteros PhD , (M)

Teresa Bennett PhD (F)

Isolde Gornemann MD PhD MPH (F).

RECENT RELEVANT PAPERS

1: Ballesteros J, Ransom J, In-Target versus Off-Target allosteric modulators of GPCRs Drug Discovery Today: Therapeutic Strategies, Vol 3, Issue 4, 2006, Pages 445-450

2: Deupi X, Dolker N, Lopez-Rodriguez ML, Campillo M, Ballesteros JA, Pardo L. Structural models of class a G protein-coupled receptors as a tool for drug design: insights on transmembrane bundle plasticity. Curr Top Med Chem. 2007;7(10):991-8. Review.

3: Salom D, Lodowski DT, Stenkamp RE, Le Trong I, Golczak M, Jastrzebska B, Harris T, Ballesteros JA, Palczewski K. Crystal structure of a photoactivated deprotonated intermediate of rhodopsin. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16123-8. Epub 2006 Oct 23.

4: Jongejan A, Bruysters M, Ballesteros JA, Haaksma E, Bakker RA, Pardo L, Leurs R. Linking agonist binding to histamine H1 receptor activation. Nat Chem Biol. 2005 Jul;1(2):98-103.

5: Young SM, Curry MS, Ransom JT, Ballesteros JA, Prossnitz ER, Sklar LA, Edwards BS. High-throughput microfluidic mixing and multiparametric cell sorting for bioactive compound screening. J Biomol Screen. 2004 Mar;9(2):103-11.

Patents: Ballesteros, J., Ransom, J. “Gain of function sorting for drug discovery and development”, US and PCT. Pending. Beernick, A., Ballesteros, J., Ransom J. “Multiplexed multitarget screening method” US and PCT. Pending.

Honors: Fullbrigth Scholarship for the PhD in Mount Sinai Hospital, New York, USA, 1989-1994. Obtained grants from USA NIH (National Institutes of Health) for more than $14.000.000